Expression of anti-mesothelin CAR-T cells with cell chemokine receptors CCR2b and CCR4 revealed enhanced migration of CAR-Ts in vitro and displayed high levels of cytotoxicity and increased levels of IL-2, IFN-γ, and TNF-α, revealing CCR2b as the superior chemokine receptor in NSCLC in vivo studies [106]. This evidence concerns the gene CCR2 and non-small cell lung carcinoma.