Although, as mentioned, low MBL-conferring genotypes are risk factors for development of OC, in women with malignant ovarian tumours carrying A/A genotypes, median MBL levels (as well as MBL–MASP-2 complex activities) were higher compared with A/A homozygotes found in reference groups (healthy women and patients diagnosed with benign tumours) and correlated with C-reactive protein (CRP) [25,26]. This evidence concerns the gene CRP and benign neoplasm.