This analysis allowed two subtypes of RCC to be identified: an inflammatory subtype (enriched for Treg, NK cells, neutrophils, macrophages, B-cells and CD8+ T cells) and a non-inflammatory subtype, which is characterized by enrichment for endothelial cells and low frequency of macrophages, B cells, T cells, NK cells, and neutrophils; BPRM1 gene loss; and increased angiogenesis associated with pancreatic organotropism [244,312]. The gene discussed is CD8A; the disease is renal cell adenocarcinoma.