Additionally, our data reveal that the VMF group had the highest expression of PTEN along with the cell cycle inhibitory and proapoptotic molecules that coincided with the lowest levels of CCND1, CCND3, BCL2, PI3K, Akt, and mTOR compared with all therapeutic regimens in the animals and the colon cancer cell lines used. Here, AKT1 is linked to colonic neoplasm.