This is often seen by the activation of NRF2 in melanomas, particularly in those harboring KEAP1 mutations, during progression with the upregulation of key downstream redox regulatory factors including elements of the glutathione (GSH) system, thioredoxin (TRX) system, cysteine cycling, nicotinamide adenine dinucleotide phosphate (NADPH): quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1), heat shock protein 70 (HSP70), and peroxiredoxins [51,52,53,54,55,56,57,58,59,60,61]. Here, HMOX1 is linked to melanoma.