Interestingly, mimicking SOD2 with the mitochondrial superoxide scavenger (2-(2,2,6,6-tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl) triphenylphosphonium chloride induced melanoma-cell line death and apoptosis and reduced tumor size in mouse xenografts [209]. This evidence concerns the gene SOD2 and melanoma.