RB1 and esophageal squamous cell carcinoma: Frequently mutated genes in ESCC include TP53, NOTCH1, NFE2L2, CDKN2A, PIK3CA, RB1, FAM135, ADAM29, MLL2, FBXW7, AJUBA, CREEBP, PTCH1, ZNF750, PTEN, FAT1, EP300, FAT2, KDM6A, CREBBP, BAP1, NOTCH3, TGFBR2, CUL3, DCDC1, NAV3, TENM3, TET2, RIPK4, PBRM1 and USP8 [44,52,53,54,55,56,57,58] (Figure 1, including full gene names).