As iCAFs are a source of inflammatory signals, the authors observed an increase in iCAFs upon Hedgehog inhibition, which correlated with changes in immune infiltration (significantly decreased CD8+ T cells and increased CD4+ T cells and CD25+CD4+ T cells; abundant FOXP3+ regulatory T cells) that are consistent with a more immunosuppressive pancreatic cancer microenvironment. This evidence concerns the gene CD4 and familial pancreatic carcinoma.