The role of the activation of EGFR, Wnt/beta-catenin, Hippo, TGF-beta, and JAK/STAT cascades in CAFs in relation to the chemoresistance and invasive or metastatic behavior of cancer cells [65] has strengthened the concept that CAFs should be included as a target for therapy in solid tumors. The gene discussed is CTNNB1; the disease is cancer.