Notwithstanding, even with dual inhibition of pan-class PI3K and both mTOR complexes, it can be hypothesized that, e.g., TCR/PLCγ1-NFAT, MAPK/ERK, TNFR-NF-κB and JAK/STAT signaling pathways, important in pathogenesis and progression of MF [44,45,46,47,48,49,50,51,52,53,54], could undergo upregulation upon full inhibition of the PI3K/AKT/mTOR pathway. This evidence concerns the gene PLCG1 and mycosis fungoides.