In the hitherto largest study of PD-1 and PD-L1 in DLBCL by Kiyasu et al., including 1253 DLBCL patients, high tumor cell expression of PD-L1 was associated with inferior OS (p = 0.0009), while PD-1+ TILs were not associated with OS [37]. This evidence concerns the gene PDCD1 and diffuse large B-cell lymphoma.