Additionally, we examined two genetically engineered syngeneic mouse models, one developing breast and the other prostate cancer, which develop tumors spontaneously when specific transgenes are expressed in breast (PyMT) [23,24] or prostate (c-Myc) [25,26] under control of a mammary (MMTV)- or prostate (probasin)-specific promoter, respectively (Figure 2B,C). Here, MYC is linked to prostate carcinoma.