Meanwhile, the double cKO of Vhl and BRCA1-associated protein 1 (Bap1) developed ccRCC faster than the double cKO of Vhl and polybromo 1 (Pbrm1), which encodes the BRG1-associated factor 180 (BAF180), a component of the SWI/SNF-B chromatin-remodeling complex [53]. The gene discussed is VHL; the disease is nonpapillary renal cell carcinoma.