GPX4 and acute kidney injury: The amelioration of renal IRI by the ferroptosis inhibitor was enhanced by the combination of the necrosis inhibitor that suppressed RIPK, indicating the interaction of these signaling pathways [112], while the replacement of the active selenocysteine in Gpx4 did not become sensitized to cisplatin-induced AKI, indicating that impaired Gpx4 did not aggravate all of the AKIs [113].