Also, a combination of AFP detection along with other markers seems to have a chance of increasing detectability of HCC–combination with alanine transaminase (ALT) and aspartate transaminase (AST) (that is liver function markers) [14,15], increasing detectability of AFP combined with Lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) [16], as well as combined use of AFP, AFP-L3 and des-gamma-carboxy prothrombin (DCP) [17]. This evidence concerns the gene AFP and hepatocellular carcinoma.