In combination with MET overexpression, as observed in the majority of OSCC cases [53], this results in the increased concentration of MET-EC- fragments on the tumor cell membrane thus enhancing their stabilization (e.g., by dimerization or oligomerization) and constitutive activation, as also observed by Merlin et al. in NIH-3T3 cells [45] (Figure 2B). The gene discussed is MET; the disease is neoplasm.