The TCF was tested on a cohort of 15 patients with biopsy proven prostate tumor (Gleason 6 (3 + 3) or Gleason 7 (3 + 4), or Gleason 9 (5 + 4) and increased PSA (7.11 ± 4.49) who underwent mpMRI. Here, HNF4A is linked to prostate neoplasm.