In addition, T-5224 protects from bleomycin-induced lung fibrosis, in which, however, a major role is played by Fra-2/AP-1 dimers in murine alveolar macrophages [99], while the Fra-1/AP-1 dimers exert a protective effect [100] The anti-neoplastic efficacy has been evaluated in a mouse model of HNSCC, in which T-5224 is able to inhibit cancer cell invasiveness and prevent lymph nodal metastases [101]. This evidence concerns the gene FOSB and head and neck squamous cell carcinoma.