The context-dependent roles of Fra-1 expression are pinpointed by the inhibitory effects of FOSL1 downregulation on tumor growth, detectable in KRAS-mutated but not in KRAS-wild type PDAC (Pancreatic Ductal AdenoCarcinoma) and LUAD (LUng ADenocarcinoma) cells. This evidence concerns the gene KRAS and pancreatic ductal adenocarcinoma.