Fra-1 overexpression crucially contributes to cancer cell invasion in most solid tumors, including adenocarcinoma (breast, lung, colon, pancreas, and thyroid), squamous cell carcinomas, and non-epithelial cancers, such as melanoma, malignant mesothelioma, and GBM (reviewed in [9]). The gene discussed is FOSL1; the disease is squamous cell carcinoma.