SR11302, however, does not discriminate between distinct JUN/FOS heterodimers, as shown by the SR11302 ability to block both c-Fos/AP-1 heterodimers in retinal angiogenesis [131], and Fra-1/AP-1 heterodimers in HNSCC metastatic progression [53,101]. This evidence concerns the gene JUN and head and neck squamous cell carcinoma.