Time to recurrence and/or metastasis-free survival correlate with Fra-1 expression (alone or in multivariate analyses) in a wide range of adenocarcinomas, including breast [29,34,36,50,51], colon [30,35,41,48], lung [37], pancreas [37], cholangiocarcinoma [52], and squamous cell carcinomas, such as HNSCC (Head and Neck Squamous Cell Carcinoma) [53,54], ESCC (Esophageal Squamous Cell Carcinoma) [55,56], and OSCC (Oral Squamous Cell Carcinoma) [57]), along with non-epithelial cancers, such as glioma [58]. The gene discussed is FOSL1; the disease is esophageal squamous cell carcinoma.