In HNSCC, Fra-1/AP-1 controls key pro-metastatic genes (such as FOSL1 itself, SNAI2, and miR-21) through super-enhancers, which recruit the coactivators (MED1 and BRD4) through Fra-1-dependent mechanisms [53,137]. The gene discussed is FOSL1; the disease is head and neck squamous cell carcinoma.