Using an SUVmax of 2.5 with regard to separate low and favorable intermediate risk PC vs. unfavorable intermediate and high-risk PC (GS ≤ 7a vs. ≥7b), 18F-PSMA showed that 25% GS ≤ 7a prostatic lesions and 75% GS ≥ 7b PC lesions occurred in the prostate bed in our study, while 68Ga-PSMA showed GS ≤ 7a and GS ≥ 7b prostatic bed lesions in 31% and 69% when using a SUVmax cut-off of 2.5. The gene discussed is FOLH1; the disease is pachyonychia congenita.