In addition, histopathological analysis of H&E-stained Swiss roll preparations demonstrated the presence of numerous large colorectal tumors in Stat3CCol1a2 mice (Figure 3A), which was also confirmed by LSFM, further suggesting a strong vascularization of the tumors as evidenced by staining of CD31 (Figure 3B). Here, PECAM1 is linked to colorectal neoplasm.