In DLBCL, high levels of Tim-3+Foxp3+Tregs within the TME have been considered as a prognostic factor for poor survival [58], whereas the high intratumor infiltration of CD25+FOXP3+ Tregs was correlated with a favorable prognosis in a meta-analysis [63]. The gene discussed is FOXP3; the disease is diffuse large B-cell lymphoma.