In this sense, the progression of Epstein–Barr virus (EBV)+ HL [66] or B-cell NHL [67] is suppressed by CTLs, whereas CTLs have also been associated with progression of CD8+ lymphomas, such as nodal cytotoxic T-cell lymphoma and cutaneous T-cell lymphoma (CTCL), towards their malignant transformation [68,69]. The gene discussed is CD8A; the disease is primary cutaneous T-cell non-Hodgkin lymphoma.