In addition, leukocyte subsets, as determined by CIBERSORT (https://cibersort.stanford.edu/, accessed on 31 January 2022), show that PolE-mutant endometrial tumors display much higher proportions of CD8+ T cells, T helper cells, M1 macrophages, and activated NK cells as compared to MSI-H and MSS tumors. The gene discussed is POLE; the disease is endometrium neoplasm.