A multicenter study enrolling 600 PCa patients demonstrated an overall positivity rate of 67.7% (38.7% in prostate/prostatectomy bed, 32.6% in lymph nodes, 26.2% in extrapelvic sites), and of 41.4% in patients with PSA less than 0.79 ng/mL [20]. Here, KLK3 is linked to posterior cortical atrophy.