In parallel, the immunohistochemical profile of these adenocarcinomas is characterized by the loss of INI-1 expression, positivity for CK7, CK20 (focal) and CDX2 (focal), as well as positivity for yolk sac markers like glypican-3, alpha fetoprotein and SALL4 [96]. Here, GPC3 is linked to adenocarcinoma.