The immunohistochemical profile of these adenocarcinomas is more complex, and, besides the loss of INI-1 expression, includes positivity for CK7, CK20 (focal) and CDX2 (focal), as well as for yolk sac markers including glypican-3, alpha fetoprotein and SALL4 [96]. This evidence concerns the gene SALL4 and adenocarcinoma.