NOTCH1 and acute myeloid leukemia: Interestingly, NOTCH1 is mutated in 12% of AML patients and its mutation is an adverse independent predictor factor for OS; nevertheless, the cohort analyzed was small (50 patients) and the results were not replicated, at least in part, due to the non-inclusion of Notch pathway genes in targeted NGS panels employed in myeloid malignancies [44].