In addition, E2F1 is upregulated in GC cell lines that are resistant to paclitaxel and cisplatin [147], whereas E2F1 silencing enhances the sensitivity of GC cell lines to cisplatin, doxorubicin, 5-FU, and paclitaxel plus cisplatin [146,147,148]. Here, E2F1 is linked to gastric cancer.