This classification distinguishes the following subtypes of GC: GCs showing high MSI, microsatellite-stable GCs with active TP53 (MSS/TP53+), microsatellite-stable GCs with inactive TP53 (MSS/TP53-) and microsatellite-stable tumors expressing an epithelial–mesenchymal transition (EMT) signature (MSS/EMT) [10]. This evidence concerns the gene TP53 and gastric cancer.