In turn, solamargine increased the expression of p53, Bax and Bcl-2 in U2OS and K562/A02 cells on the mRNA and protein levels, and the mRNA expression and promoter activity of EP4, as well as the protein expression of SP1 and NF-κB subunit p65 in lung cancer cell lines [225]. The gene discussed is TP53; the disease is lung carcinoma.