A variety of MSLN-targeting agents, including mAbs (e.g., EPR4509, EPR19025-42, MMOT0530A, and amatuximab), ADCs (anetumab ravtansine), immunotoxin (SSP1), and CAR-T cells have been conjugated to tracers and tested in malignancies overexpressing MSLN to determine mesothelin expression and correlate with tumor uptake and response to treatment [47]. This evidence concerns the gene MSLN and neoplasm.