VEGFA and neoplasm: Under the stimulation of cytokines, such as colony-stimulating factor-1 (CSF-1), IL-4, IL-10, TGF- β, and IL-13, M2 subsets are activated and secrete inflammatory inhibitory factors such as IL-10, Arg-1, chitinase-like protein (Ym1), and VEGF, which are closely related to tumor growth, development, invasion, and metastasis [62].