MMP14 and breast cancer: However, Nicolas Rabas et al. found that tumor cells can promote the release of mtDNA-containing extracellular vesicles (EVs), allowing EVs to maintain their own growth and activating TLR9 to drive endosomal trafficking of the membrane type 1 matrix metalloproteinase (MT1-MMP), which promotes the destruction of the mammary basement membrane, thereby promoting breast cancer invasiveness [151].