In particular, T cells co-cultured with PBNP-PTT-treated SH-SY5Y (MYCN-non-amplified) and LAN-1 (MYCN-amplified) exhibited significantly higher cytotoxicity toward SH-SY5Y cells compared with LAN-1 cells, where minimal to negligible tumor cell killing by T cells was observed (Figure 7). Here, MYCN is linked to neoplasm.