Of note, 8-Cl-Ado treatment of primary AML cells resulted in the significant inhibition of a gene set involved in transcription regulation by RNA Pol I (FDR 0.03) (Figure 2E), suggesting that 8-Cl-Ado inhibits proper formation of the Pol I pre-initiation transcription complex through downregulation of TIF-IA. Here, RRN3 is linked to acute myeloid leukemia.