We observed that 8-Cl-Ado treatment of LSC-enriched primary AML cells disrupted the colocalization of TIF-IA and UBF at the rDNA site, as demonstrated by immunofluorescent and fluorescent in situ hybridization (IF-FISH) with anti-TIF-IA, anti-UBF antibodies and rDNA probes (Figure 2A). Here, UBTF is linked to acute myeloid leukemia.