Furthermore, 8-chloro-adenosine (8-Cl-Ado) is one such analog that is RNA-directed and targets LSCs without significantly inhibiting HSCs [15,16], inhibits FLT3-ITD signaling and has shown anti-neoplastic activity in vitro and in vivo, including in AML [15,16,17,18]. Here, FLT3 is linked to acute myeloid leukemia.