NFE2L2 and acute myeloid leukemia: We and others demonstrated that the VEN/HMA combination augments oxidant stress in AML cells and we provided a molecular mechanism of a VEN-HMA-regulated NF-E2-related factor 2 (Nrf2) antioxidant pathway that could explain the impressive results observed in early clinical studies in AML [38], but mechanisms of resistance remain to be fully elucidated.