In keeping with this view, the rare mixed form of hepato-cholangiocarcinoma, a tumor presenting histological hallmarks of both HCC and CCA, has been associated with liver cirrhosis in 50–80% of cases [97].Another point supporting similar carcinogenic mechanism for both HCC and CCA in cirrhosis is the frequent changes in p53 observed [98]. This evidence concerns the gene TP53 and cirrhosis of liver.