INS and obesity due to melanocortin 4 receptor deficiency: The loss of mass and muscle function can also be favored by obesity as an independent risk factor due to related alterations: chronic low-grade inflammation, an increase in oxidative stress, insulin resistance (with a decrease in the anabolic capacity of the musculature striata, in addition to the worsening of the carbohydrate profile), a sedentary lifestyle and the higher incidence of chronic diseases, which can have a negative impact on catabolism muscle [74].