There are historic data of GzmB clearing infections due to the apoptosis of infected cell types; however, GzmB has been found to cleave multiple viral proteins that play a critical role in viral replication and/or host evasion, such as herpes simplex virus (HSV) ICP27, HSV ICP4, varicella-zoster virus (VZV) ORF4, and VZV ORF62 [74]. The gene discussed is GZMB; the disease is infection.