Knockout of PINCH1 in lung adenocarcinoma cells resulted in increased DRP1 expression and therefore mitochondria fission, which led to a reduction in the level of pyrroline-5-carboxylate reductase 1 (PYCR1), an essential enzyme in proline synthesis, therefore reducing proline synthesis (Figure 1B) [24]. The gene discussed is PYCR1; the disease is lung adenocarcinoma.