Two advanced non-mucinous EOC patients, who carried germline PV/LPV (deletion of exons 1 and 2 in BRCA1 and c.5932G > T in ATM), which were not detected in tumor testing, had a diagnosis of high grade serous ovarian cancer and no family history of breast and ovarian cancer. This evidence concerns the gene ATM and ovarian serous adenocarcinoma.