NF1 and plexiform neurofibroma: We evaluated if the CAs number at baseline could possibly be correlated with the quantity of other NF1-related signs (i.e., CALMs, atypical freckling, neurofibromas, OPG, LNs and distinctive osseous lesions) expressed by the children at the age of 8, when penetrance of the disease is complete in 95% of cases, or with the type of genetic mutation (i.e., missense, frameshift, splicing, deletions and nonsense) responsible for NF1.