Since expression of both α-syn and nestin is suppressed dose-dependently within GBM cells (Figure 7, Figure 8 and Figure 10 and Supplementary Figures S1–S4) the present piece of data answers the seminal question of whether conditional overexpression of both proteins in GBM-primed astrocytes could be occluded by exposure to doses of rapamycin at therapeutic range (up to 100 nM). The gene discussed is NES; the disease is glioblastoma.