GLS and cancer: There are several approved anticancer agents that target cancer metabolism (e.g., methotrexate, 5-fluorouracil, gemcitabine); however, there are metabolic inhibitors currently in clinical trials that target more newly appreciated key elements of metabolic reprogramming such as glutaminase (CB-839, IPN60090), lactate symporters (AZD-3965), and fatty acid synthesis (TVB-2640) [225].