Further, the reduced viability of U251 cells treated with MET was found to be related with the reduction of hypoxia-inducible factor (HIF-1α) and vascular endothelial growth factor (VEGF), key actors of glioblastoma angiogenesis, as well as with the inhibition of PI3K/mTOR axis [20]. This evidence concerns the gene HIF1A and glioblastoma.