LCa cell lines (H661, A-549 and H1299) exhibited lower SETD7 levels compared with non-malignant human bronchial epithelial cells (BEAS-2B) [64] and analysis of SETD7 mRNA levels in 10 pairs of LCa tissue with matched noncancer tissues showed that SETD7 was significantly lower in LCa tissues. This evidence concerns the gene SETD7 and Leber congenital amaurosis.