SETD7 and neoplasm: Later, Wang et al. carried out a transcriptomic analysis of LNCaP cell line with SETD7 knockdown, with or without PEITC, and found a strong upregulation of the retinoic acid receptor responder 3 (RARRES3) and the antioxidant gene, SOD2, when SETD7 expression was inhibited [76], reinforcing the SETD7 tumour-promoter role through the protection of oxidative stress in PCa cells.