SETD7 methylates E2F-1 at K185 stabilising it to enhance the transcription of pro-apoptotic target genes, BIM1 and TP73, suggesting that SETD7 activity inhibits cell growth and enhances the E2F-1 pro-apoptotic effect in osteosarcoma cells [50] (Figure 6a). Here, E2F1 is linked to osteosarcoma.