These results suggest that loss of SETD7 may contribute to GC cells proliferation and invasion and is supported by lower levels of SETD7 mRNA and/or protein in a panel of 12 GC cell lines (AGS, GCIY, HSC-43, HSC-44PE, HSC-57, HSC-60, NUGC-4, KATO-III, MKN7, MKN45, MKN74 and TGBC11TKB) compared with three non-cancerous gastric mucosa samples, by RT-PCR and WB. Here, SETD7 is linked to gastric cancer.