Wnt-target gene (Axin2, Myc and Lgr5) expression was increased in the small intestine tumour tissue compared to normal tissue from both ApcMin/+/Setd7−/− and ApcMin/+/Setd7+/− mice, but more in tumours from ApcMin/+/Setd7+/−. The gene discussed is LGR5; the disease is neoplasm.