All studies showed that, independently of the type of cancer (BlaCa, BC, CRC, GC, HCC and LCa), knockdown of SETD7 by siRNAs or the inhibition of its activity by (R)-PFI-2 promoted EMT [34,36,59,63] and consequently invasion, migration [34,36,55,57,63,64] and eventually metastasis [36,59]. The gene discussed is SETD7; the disease is colorectal carcinoma.