On the other hand, under non-stress conditions, SETD7 seems to act as tumour suppressor since its downregulation increases the activation of JAK/STAT3 signalling to stimulate cell proliferation, migration [63] and invasion [64] pathways, as well as enhances HIF-1α stability to promote angiogenesis and tumour growth [39]. The gene discussed is SETD7; the disease is neoplasm.