SHH and neoplasm: Since both SETD7 and GLI1 mRNA levels were upregulated in A-549 cell line when compared to the non-malignant bronchial epithelial lung cell line BEAS-2B, it is likely that SETD7 activates the SHH signalling in LCa promoting tumour growth and metastasis in vitro and in vivo via GLI3 methylation [66] (Figure 5b).