ERBB2 and cervical squamous intraepithelial neoplasia: The CIN subtype is characterised by frequent TP53 mutations and amplifications of the genes responsible of the receptor tyrosine kinase proteins (RTKs, such EGFR, ERBB2 (HER2), ERBB3, FGFR2 and MET), KRAS or NRAS, cell-cycle mediators and VEGFA. Finally, the GS subtype, mostly represented in the distal stomach, enriched by the diffuse histology and with CDH1 or RHOA mutations, or the CLD18-ARHGAP26/6 translocation.