FCGR2A and colorectal carcinoma: In a recent comparison of CD16-CAR-T and CD32-CAR-T cells in KRAS-mutated colorectal carcinoma, even though CD32 was able to effectively bind soluble mAbs and provide a cytotoxic signal, CD32-CAR-T cells did not produce pro-inflammatory cytokines when co-cultured with KRAS-mutated HCT116 colorectal cancer cells, and they had no effect on HCT116 cell viability.