CD247 and neoplasm: The T cells, armed with ADCC capabilities via the Fc receptor FcγR IIIa (CD16) with a valine residue at position 158 (which confers increased Fc binding and tumor cell killing) when combined with the T-cell stimulatory molecule CD3ζ and the co-stimulatory molecule 4–1BB, exhibited sustained proliferation and were cytotoxic to antibody-targeted cancer cells.