To test our hypothesis and further investigate the role of AURKA in the UPR pathway, we examined the protein expression levels of AURKA and critical UPR signaling proteins in three normal esophageal tissues (NE1, NE2, and NE3), Barrett’s esophagus (BART and CPB), and esophageal adenocarcinoma cell lines (FLO-1 OE33, SK-GT4, and ESO26). The gene discussed is AURKA; the disease is esophageal adenocarcinoma.