Vice versa, NT5DC2 expression did not show any correlation with the presence of CD34+ CAFs, but NT5DC2 protein overexpression resulted in an insignificant increase of SMA+ CAFs, that themselves are a marker of tumoral stromal remodeling [43] and more advanced tumor stages and lymphonodal spread in NSCLC [35]. The gene discussed is SMN1; the disease is neoplasm.