TP53 and leukoencephalopathy with calcifications and cysts: When evaluating the cause of CD34-CAF association with p53, we previously stated, that CD34+ CAFs were primarily found in ADC patients (i.e., mean 14.3 (± 22.1)% of CAFs) but not in SCC (i.e., mean 2.9 (±5.5)% of CAFs) or LCC (i.e., mean 2.6 (±5.1)% of CAFs) (One way ANOVA p < 0.001) [37] and likewise p53 IRS was higher in SCC (i.e., mean 3.8 (±3.7) IRS score) than in ADC (i.e., mean 1.5 (±2.5) IRS score) or LCC (i.e., mean 3.0 (±3.5) IRS score) (One way ANOVA p < 0.001).