CXCL8 and neoplasm: However, with respect to the tumor microenvironment of colorectal cancer, it has been shown that cancer associated fibroblasts (CAFs) promote monocyte adhesion by secreting IL-8 and therefore enrich the tumor microenvironment with tumor-promoting M2 TAMs [40], and in parallel, influence vascular remodeling by upregulating VEGFa [41].