Mice implanted with CAIX positive murine colon adenocarcinoma cells CT-26 treated with the fusion protein IL2-Anti-CAIX(XE114)-TNFmut and IL2-Anti-CAIX(F8)-TNFmut showed around 60% reduction in tumor volume compared to the control group injected with PBS after 18 days of treatment [28]. Here, IL2 is linked to neoplasm.