We compared expression profiles between each cell line and assessed the resulting differentially expressed genes using gene set enrichment analysis (GSEA) to identify transcriptional programs differentially regulated between METΔex14 and MET-amplified lines under conditions of MET stimulation, with a focus on the “Oncogenic Signatures” library of gene sets representing transcriptional signatures of cellular pathways known to be dysregulated in cancer (Figure 1C). This evidence concerns the gene MET and cancer.