Advancements in research have revealed that the signaling pathways regulating pancreatic cancer tumorigenesis, including RAS, PI3K/Akt, NFkB, JAK/STAT, Hippo/YAP, and Wnt, have been linked to cancer-related cellular processes of cell proliferation, differentiation, apoptosis, migration, angiogenesis, metabolism, and immune regulation [68]. This evidence concerns the gene NFKB1 and cancer.