The tested sirtuins were selected on the basis of their role in cancer cells, i.e., SIRT 1 and 2 are associated with cancer stem cells; SIRT3 is an important mitochondrial deacetylase responsible for reducing oxidative stress and ROS production; SIRT6 has been proposed as a prognostic indicator and a potential therapeutic target in colon cancer. The gene discussed is SIRT3; the disease is cancer.