It shares many of the genomic and protein alterations that are exhibited by high grade-prostatic intraepithelial neoplasia and prostate cancer, such as ERG fusion and a lower expression of NKX3.1, strongly suggesting a potential preneoplastic transition and indicating an association between inflammation with the progression to prostate cancer [41,42]. The gene discussed is NKX3-1; the disease is Familial prostate cancer.