By contrast, heritable Parkinson’s disease is clearly a disease of mitochondria, since the most common genetic forms of Parkinsonism are linked to mutations of genes encoding mitochondrial PINK1 kinase (PARK6) that initiates mitophagy, as well as the principal mitophagy effector protein, Parkin (PARK2) [76]. This evidence concerns the gene PROS1 and Parkinson disease.