STAT3 and neoplasm: In addition to PI3K/AKT/mTOR, other pathways (e.g., RAS-RAF-MEK-extracellular signal-regulated kinase (ERK), small mother against decapentaplegic (SMAD), Wnt, Notch, Hedgehog, signal transducer and activator of transcription 3 (STAT3), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB)), can induce EMT in tumor cells [10].