AGT and ovarian carcinoma: Similar results were observed in an investigation of the steroidal lactone Withaferin A. Used for its anti-inflammatory characteristics and ability to impede tumor growth, Withaferin A administration to cachectic mice with ovarian cancer reduced tumor-associated increases in angiotensin II and subsequently reduced cardiomyocyte cross-sectional area loss, systolic and diastolic dysfunction, and fibrotic deposition [59].